Our laboratory aims to make cellular and molecular therapies more effective and practical approaches to treat disease. Basic science studies are used to study the mechanisms by which chemical or mechanical signals are sensed by cells and alter cell function. The results of these studies are then used to design new biomaterials that provide desirable cues in a spatiotemporally-regulated manner to modulate the gene expression of interacting cells. These biomaterials are used in a variety of drug delivery, immunotherapy, and regenerative medicine projects to promote the regeneration or targeted destruction of tissues and organs in the body.
We are grateful for the generous support of the National Institute of Health (NIH), including the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Cancer Research (NCI), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the National Heart Lung and Blood Institute (NHLBI). Additionally, we gratefully acknowledge the generous support of the National Science Foundation (NSF), the Department of Defense (DoD), the Cancer Research Institute (CRI), the Canadian Institutes of Health (CIHR), the Swiss National Science Foundation (SNSF), the European Commission, the Gary Michelson Foundation, Novartis, Amgen, Merck, the John A. Paulson School of Engineering and the Wyss Insitute at Harvard University.