News

Clickable, acid labile immunosuppressive prodrugs for in vivo targeting published in Biomaterial Science

January 1, 2020

Congrats to Hua and team on their recent publication which describes DBCO-modified prodrugs of various immunosuppressive drugs and their targeted conjugation to azido-modified hydrogels via Click chemistry. Placement of these hydrogels in tissues facilitates sustained, local release of drugs and enables repeatable refilling via systemic administration of acid-labile prodrugs after drug...

Read more about Clickable, acid labile immunosuppressive prodrugs for in vivo targeting published in Biomaterial Science

Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation published in PNAS

July 30, 2019
Congrats to Angelo and team on their recent publication which describes a microfluidic-based biomaterial encapsulation approach to improve the in vivo residence time of intravenously delivered MSCs - these modifications extended cell persistence even in the presence of innate and adaptive immunity-mediated clearance. Check it out here: ... Read more about Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation published in PNAS

Bioinspired mechanically active adhesive dressings to accelerate wound closure published in Science Advances

July 24, 2019
Congrats to Serena, Jianyu, and team on their recent publication which describes a novel wound dressing that combines high stretchability, toughness, tissue adhesion, and antimicrobial function to actively contract and seal wounds. Check it out here: Bioinspired mechanically... Read more about Bioinspired mechanically active adhesive dressings to accelerate wound closure published in Science Advances
Kyle_aECM

Sequential modes of crosslinking tune viscoelasticity of cell-instructive hydrogels published in Biomaterials!

January 1, 2019
Congrats to Kyle and team on their recent publication which describes the development of an articial extracellular matrix (ECM) that mimics the fibrillar architecture of natural ECM while supporting independent regulation of its mechanical properties. Check it out here: ... Read more about Sequential modes of crosslinking tune viscoelasticity of cell-instructive hydrogels published in Biomaterials!

Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice published in PNAS!

November 1, 2018

Congrats to Theresa on her recent publication which shows that cytokines coupled to gold nanoparticles can be used to direct macrophage polarization following muscle injury in vivo. Check it out here: Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in...

Read more about Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice published in PNAS!