News

Kyle_aECM

Sequential modes of crosslinking tune viscoelasticity of cell-instructive hydrogels published in Biomaterials!

January 1, 2019
Congrats to Kyle and team on their recent publication which describes the development of an articial extracellular matrix (ECM) that mimics the fibrillar architecture of natural ECM while supporting independent regulation of its mechanical properties. Check it out here: ... Read more about Sequential modes of crosslinking tune viscoelasticity of cell-instructive hydrogels published in Biomaterials!

Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice published in PNAS!

November 1, 2018

Congrats to Theresa on her recent publication which shows that cytokines coupled to gold nanoparticles can be used to direct macrophage polarization following muscle injury in vivo. Check it out here: Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in...

Read more about Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice published in PNAS!
2018_summer_undergrads

Mooney lab summer students present research

August 4, 2018

Congrats to all Mooney lab undergraduates on a productive summer! Great to see such a wide breadth of projects ranging from cell biology to hydrogel mechanics.

Pictured from left: Calvin Marambo, Ege Eskibozkurt, Justine Keth, Luna Nadja Maldonado, Nikko Jeffries, Darnell Cuylear, Soore Oguntuyo, Anna Vaynrub, Evan Thompson

PLGA scaffold

Biomaterial scaffold-based immunotherapy platforms licensed to Novartis

March 31, 2018

The Wyss Institute at Harvard Universtiy and Dana-Farber Cancer Institute have entered a licensing and collaboration agreement with Novartis to develop our biomaterial systems to delivery next generation immunotherapies. Our approach uses an injectable or implantable biomaterial scaffold that recruits and trains the body's endogenous immune cells to identify and kill a patient's own cancerous cells. A big congratulations to Dave...

Read more about Biomaterial scaffold-based immunotherapy platforms licensed to Novartis

A facile approach to enhance antigen response for personalized cancer vaccination published in Nature Materials

March 22, 2018
Congrats to Aileen and team on their recent publication which looked at using polyethyleneimine (PEI) in mesoporous silica rod (MSR) vaccines to enhance antigen immunogenicity. The MSR-PEI vaccine substantially improved therapeutic outcomes in three challenging tumor models while enabling the presentation of large sets of neoantigens and synergizing with checkpoint blockade therapy. Check out their work here: ... Read more about A facile approach to enhance antigen response for personalized cancer vaccination published in Nature Materials