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Mooney lab summer students present research

August 4, 2018

Congrats to all Mooney lab undergradautes on a productive summer! Great to see such a wide breath of projects ranging from cell biology to hydrogel mechanics.

Pictured from left: Calvin Marambo, Ege Eskibozkurt, Justine Keth, Luna Nadja Maldonado, Nikko Jeffries, Darnell Cuylear, Soore Oguntuyo, Anna Vaynrub, Evan Thompson

CD4 T-cells regulate angiogenesis and myogenesis published in Biomaterials

June 10, 2018

Congrats to Brian and team on their recent publication which looked at the role of various CD4+ T cell subsets on muscle regeneration. Check it out here: CD4 T-cells regulate angiogenesis and myogenesis!

Mooney Lab seniors honored for outstanding projects

May 15, 2018

Congrats to Mooney Lab senior undergraduates Erica Budina, Kristen Rodrigues, and Jacob Scherba on being honored by SEAS Dean Frank Doyle for the outstanding work on their thesis projects! Well done guys! Click here for the whole story.

Photo credit: SEAS, Harvard University

Biomaterial scaffold-based immunotherapy platforms licensed to Novartis

March 31, 2018

The Wyss Institute at Harvard Universtiy and Dana-Farber Cancer Institute have entered a licensing and collaboration agreement with Novartis to develop our biomaterial systems to delivery next generation immunotherapies. Our approach uses an injectable or implantable biomaterial scaffold that recruits and trains the body's endogenous immune cells to identify and kill a patient's own cancerous cells. A big congratulations to Dave...

A facile approach to enhance antigen response for personalized cancer vaccination published in Nature Materials

March 22, 2018

Congrats to Aileen and team on their recent publication which looked at using polyethyleneimine (PEI) in mesoporous silica rod (MSR) vaccines to enhance antigen immunogenicity. The MSR-PEI vaccine substantially improved therapeutic outcomes in three challenging tumor models while enabling the presentation of large sets of neoantigens and synergizing with checkpoint blockade therapy. Check out their work here: ... Read more about A facile approach to enhance antigen response for personalized cancer vaccination published in Nature Materials

Injectable, Tough Alginate Cryogels as Cancer Vaccines and Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs published in Advanced Healthcare Materials

March 15, 2018

Congrats to Ting and Jianyu on their recent publications in Advanced Healthcare Materials. Ting's article explored using injectable, tough alginate cryogels as prophylactic cancer vaccines and Jianyu's article explored using tough composite hydrogels to enable high loading and sustained release...

Congratulations to Max Darnell

March 2, 2018

A big congrats to recent PhD graduate Max Darnell, who is headed to Georg Seelig's quantiative biology lab at the University of Washington to pursue his postdoctoral studies. His positive energy and expertise will be missed by all. Congrats and best of luck in your...

Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells published in Nature Biotechnology

February 13, 2018

Congrats to Alex, David, and Sandeep on their recent publication which looked at making adoptive cell therapies more efficient. Their work was also highlighted on the cover of this month's issue of ... Read more about Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells published in Nature Biotechnology

Covalent Conjugation of Peptide Antigen to Mesoporous Silica Rods to Enhance Cellular Responses published in Bioconjugate Chemistry

January 11, 2018

Congrats to Maxence on his new publication which looks at conjugating short peptides to mesoporous silica rods to improve retention and potentiate cellular responses. Check it out here.

Congratulations to Aileen Li

January 2, 2018

A big congratulations to Aileen Li, who defended her PhD thesis earlier this year. Aileen was one of the pioneers of the injectable, mesoporous silica vaccine platform. She will be heading to Wendell Lim's synthetic biology lab at UCSF to conduct her postdoctoral studies. Her many scientific contributions to the lab, presence, and positive energy will be... Read more about Congratulations to Aileen Li

Latest News

Mooney lab summer students present research

August 4, 2018

Congrats to all Mooney lab undergradautes on a productive summer! Great to see such a wide breath of projects ranging from cell biology to hydrogel mechanics.

Pictured from left: Calvin Marambo, Ege Eskibozkurt, Justine Keth, Luna Nadja Maldonado, Nikko Jeffries, Darnell Cuylear, Soore Oguntuyo, Anna Vaynrub, Evan Thompson

CD4 T-cells regulate angiogenesis and myogenesis published in Biomaterials

June 10, 2018

Mooney Lab seniors honored for outstanding projects

May 15, 2018

Photo credit: SEAS, Harvard University

Biomaterial scaffold-based immunotherapy platforms licensed to Novartis

March 31, 2018

For more information on our technology, please have a look at the immunotherapy research section.

To view the Novartis press release, click here.

Photo credit: Wyss Institute at Harvard University

A facile approach to enhance antigen response for personalized cancer vaccination published in Nature Materials

March 22, 2018

Congrats to Aileen and team on their recent publication which looked at using polyethyleneimine (PEI) in mesoporous silica rod (MSR) vaccines to enhance antigen immunogenicity. The MSR-PEI vaccine substantially improved therapeutic outcomes in three challenging tumor models while enabling the presentation of large sets of neoantigens and synergizing with checkpoint blockade therapy. Check out their work here: A facile approach to enhance antigen response for personalized cancer vaccination.

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