Congrats to Hua and team on their recent publication which describes DBCO-modified prodrugs of various immunosuppressive drugs and their targeted conjugation to azido-modified hydrogels via Click chemistry. Placement of these hydrogels in tissues facilitates sustained, local release of drugs and enables repeatable refilling via systemic administration of acid-labile prodrugs after drug...
Congrats to Hua and team on their recent publication which describes DBCO-modified prodrugs of various immunosuppressive drugs and their targeted conjugation to azido-modified hydrogels via Click chemistry. Placement of these hydrogels in tissues facilitates sustained, local release of drugs and enables repeatable refilling via systemic administration of acid-labile prodrugs after drug exhaustion. Such an approach provides new possibilities for targeted immunosuppression in the context of allotransplantation.
Congrats to Angelo and team on their recent publication which describes a microfluidic-based biomaterial encapsulation approach to improve the in vivo residence time of intravenously delivered MSCs - these modifications extended cell persistence even in the presence of innate and adaptive immunity-mediated clearance. Check it out here: Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation
