• APC-ms

    Antigen presenting cell-mimetic scaffolds

    Credit: Alex Cheung, David Zhang, Sandeep Koshy

  • Tough adhesive

    Tough adhesive

    Credit: Jianyu Li, Adam Celiz, Wyss Institute.

  • Mesoporous silica rods

    Mesoporous silica rods

    Credit: Aileen Li, James Weaver

  • Dental pulp stem cells

    Dental pulp stem cells on regenerative biomaterial

    Credit: Kyle Vining

  • Encapsulated mesenchymal stem cell in alginate microgel

    Encapsulated mesenchymal stem cell in alginate microgel

    Purple: alginate, yellow: actin, blue: nucleus. Credit: Angelo Mao.

Welcome!

The Mooney lab focuses on making therapies more effective and practical. Our research involves exploiting our understanding of cell and molecular biology to design biomaterials that effect and potentiate specific cell functions. The lab members consist of post-doctoral fellows, graduate and undergraduate students, research fellows, and visiting scholars from diverse academic backgrounds. For more information, please visit our publications page, and for any inquiries, please visit our contact page.

Latest News

Biomaterial scaffold-based immunotherapy platforms licensed to Novartis

March 31, 2018
PLGA scaffold

The Wyss Institute at Harvard Universtiy and Dana-Farber Cancer Institute have entered a licensing and collaboration agreement with Novartis to develop our biomaterial systems to delivery next generation immunotherapies. Our approach uses an injectable or implantable biomaterial scaffold that recruits and trains the body's endogenous immune cells to identify and kill a patient's own cancerous cells. A big congratulations to Dave, Omar, and team! We've still got a lot of work to do.

For more information on our technology, please have a look at the immunotherapy research section

To view the Novartis press release, click here.

Photo credit: Wyss Institute at Harvard University

A facile approach to enhance antigen response for personalized cancer vaccination published in Nature Materials

March 22, 2018
Congrats to Aileen and team on their recent publication which looked at using polyethyleneimine (PEI) in mesoporous silica rod (MSR) vaccines to enhance antigen immunogenicity. The MSR-PEI vaccine substantially improved therapeutic outcomes in three challenging tumor models while enabling the presentation of large sets of neoantigens and synergizing with checkpoint blockade therapy. Check out their work here: A facile approach to enhance antigen response for personalized cancer vaccination.

Injectable, Tough Alginate Cryogels as Cancer Vaccines and Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs published in Advanced Healthcare Materials

March 15, 2018

Congrats to Ting and Jianyu on their recent publications in Advanced Healthcare Materials. Ting's article explored using injectable, tough alginate cryogels as prophylactic cancer vaccines and Jianyu's article explored using tough composite hydrogels to enable high loading and sustained release of biological payloads. Check out their work here:

Injectable, Tough Alginate Cryogels as Cancer Vaccines

Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs

Congratulations to Max Darnell

March 2, 2018

A big congrats to recent PhD graduate Max Darnell, who is headed to Georg Seelig's quantiative biology lab at the University of Washington to pursue his postdoctoral studies. His positive energy and expertise will be missed by all. Congrats and best of luck in your new position Max!

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