Yevgeny Brudno

Yevgeny Brudno

Technology Development Fellow
Yevgeny Brudno



  • PhD: Department of Chemistry and Chemical Biology. Harvard University.  Advisor: David R. Liu
  • BS: Chemistry, Biophysics.   University of Pennsylvania Magna Cum Laude

Research Focus

Drug Delivery, Angiogenesis, Cancer Therapeutics


“In Vivo Disease Targeting through Click Chemistry.” Brudno Y, Kwee B, Desai R, Aizenberg M, Mooney DJ.  ChemMedChem. In press.

“Panel of 3D in vitro models to study impaired wound healing functions of diabetic foot ulcer-derived fibroblasts.” Maione AG, Brudno Y, Stojadinovic O, Park, LK, Smith, A, Tellechea A, Leal EC, Kearney C, Veves A, Tomic-Canic M, Mooney DJ, Garlick JA. Tissue Engineering Part B. In Press.

Refilling Drug Delivery Depots Through the Blood.” Brudno Y*, Silva EA*, Kearney CJ, Lewin S, Aizenberg M, Mooney DJ. Proceedings of the National Academy of Science 111(35): 12722-7 (2014)


“Fibroblasts Derived from Human Pluripotent Stem Cells Activate Angiogenic Responses In Vitro and In Vivo.” Shamis Y, Silva EA, Hewitt KJ, Brudno Y, Levenberg S, Mooney DJ, Garlick JA. PLoS ONE 8(12): e83755. 2013

“Spatiotemporal Control Over Growth Factor Signaling for Therapeutic Angiogenesis.” Brudno Y, Ennet AB, Chen R, Aizenberg M, Mooney DJ.  Biomaterials. 34(36):9201-9. 2013

“Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.” Pastor WA, Pape UJ, Huang Y, Henderson HR, Lister R, Ko M, McLoughlin EM, Brudno Y, Mahapatra S, Kapranov P, Tahiliani M, Daley GQ, Liu S, Ecker JR, Milos PM, Agarwal S, Rao A. Nature 473:394. 2011 

“An In Vitro Translation, Selection, and Amplification System for Peptide Nucleic Acids".  Brudno Y, Birnbaum ME, Kleiner RE, Liu DR. Nature Chemical Biology 6: 148-155. 2009

“Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.” Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A. Science 324(5929): 930-5. 2009

“Recent progress toward the templated synthesis and directed evolution of sequence-defined synthetic polymers.” Brudno Y, Liu DR. Chemistry & Biology 16(3): 265-76. 2009

"DNA-Templated Polymerization of Side-Chain-Functionalized Peptide Nucleic Acid Aldehydes" Kleiner RE, Brudno Y, Birnbaum ME, Liu DR. Journal of the American Chemical Society 130 (14): 4646 – 4659. 2008


“Polymer evolution via templated synthesis.” Liu DR, Rosenbaum DR, Brudno Y.  U.S. patent application no. 11916710.

Contact Information

Current: Assistant Professor at UNC/NC Sate joint BME Department