#  Research Overview 

 



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Our laboratory aims to make cellular and macromolecular therapies more effective and practical approaches to treat disease. Basic science studies are used to study the mechanisms by which chemical or mechanical signals are sensed by cells and alter cell function. The results of these studies are then used to design new biomaterials that provide desirable cues in a spatiotemporally-regulated manner to modulate the gene expression of interacting cells. These biomaterials are used in a variety of drug delivery, immunotherapy, and regenerative medicine projects to promote the regeneration or targeted destruction of tissues and organs in the body.



 

 We are grateful for the generous support of the following funding sources:

 ![2021FundingSources](/sites/g/files/omnuum6436/files/mooneylab/files/2021fundingsources.jpg)

 



 

##  Latest News 

 



  [### Implantable living materials autonomously deliver therapeutics using contained engineered bacteria

 ](/news/2026/05/implantable-living-materials-autonomously-deliver-therapeutics-using-contained) May 14, 2026 

 Congratulations to Tetsu and team for their new publication in Science on engineering bacteria for sustained drug delivery. 

 

 

   ![Figure 1](/sites/g/files/omnuum6436/files/styles/hwp_16_9__480x270/public/2026-05/Figure%201.jpg?itok=Ls5Zh7c8) 

 



 

 

   [### Favour Obuseh defends his PhD thesis

 ](/news/2026/05/favour-obuseh-defends-his-phd-thesis) May 11, 2026 

 Congratulations to Dr. Obuseh on defending his doctoral thesis on Monday, May 4th, on Enhancing Gamma Delta (γδ) T-Cell Therapies Through Engineered Biochemical and Mechanical Microenvironments. Favour is going on to attend Yale School of Medicine to... 

 

 

   ![Favour and Professor Mooney](/sites/g/files/omnuum6436/files/styles/hwp_16_9__480x270/public/2026-05/Favour%20and%20dave_0.jpg?itok=gv_u2x4S) 

 



 

 

   [### Nikko Jeffreys defends his thesis 

 ](/news/nikko-jeffreys-defends-his-thesis) September 30, 2024 

 Congratulations to Dr.Jeffreys on sucessfully defending his amazing thesis on applying mechanotransduction in human T-cell development to enhance immunotherapy. We are very proud of you :) 

 

 

   ![Nikko Jeffreys](/sites/g/files/omnuum6436/files/styles/hwp_16_9__480x270/public/nikko.jpg?itok=361nX-01) 

 



 

 

  

 

 [ More arrow\_circle\_right ](/news)