@article {743901,
	title = {The effect of surface modification of mesoporous silica micro-rod scaffold on immune cell activation and infiltration},
	journal = {Biomaterials},
	volume = {83},
	year = {2016},
	month = {2016 Mar},
	pages = {249-56},
	abstract = {Biomaterial scaffold based vaccines show significant potential in generating potent antigen-specific immunity. However, the role of the scaffold surface chemistry in initiating and modulating the immune response is not well understood. In this study, a mesoporous silica micro-rod (MSR) scaffold was modified with PEG, PEG-RGD and PEG-RDG groups. PEG modification significantly enhanced BMDC activation marker up-regulation and IL-1β production in vitro, and innate immune cell infiltration in vivo. PEG-RGD MSRs and PEG-RDG MSRs displayed decreased inflammation compared to PEG MSRs, and the effect was not RGD specific. Finally, the Nlrp3 inflammasome was found to be necessary for MSR stimulated IL-1β production in vitro and played a key role in regulating immune cell infiltration in vivo. These findings suggest that simply modulating the surface chemistry of a scaffold can regulate its immune cell infiltration profile and have implications for the design and development of new material based vaccines.},
	keywords = {Animals, Bone Marrow Cells, Carrier Proteins, Cytokines, Dendritic Cells, Female, Inflammasomes, Mice, Inbred C57BL, NLR Family, Pyrin Domain-Containing 3 Protein, Porosity, Silicon Dioxide, Surface Properties, Tissue Scaffolds},
	issn = {1878-5905},
	doi = {10.1016/j.biomaterials.2016.01.026},
	author = {Li, Weiwei Aileen and Lu, Beverly Ying and Gu, Luo and Choi, Youngjin and Kim, Jaeyun and Mooney, David J}
}
