@article {601636,
	title = {Injectable cryogel-based whole-cell cancer vaccines},
	journal = {Nat Commun},
	volume = {6},
	year = {2015},
	month = {2015 Aug 12},
	pages = {7556},
	abstract = {A biomaterial-based vaccination system that uses minimal extracorporeal manipulation could provide in situ enhancement of dendritic cell (DC) numbers, a physical space where DCs interface with transplanted tumour cells, and an immunogenic context. Here we encapsulate GM-CSF, serving as a DC enhancement factor, and CpG ODN, serving as a DC activating factor, into sponge-like macroporous cryogels. These cryogels are injected subcutaneously into mice to localize transplanted tumour cells and deliver immunomodulatory factors in a controlled spatio-temporal manner. These vaccines elicit local infiltrates composed of conventional and plasmacytoid DCs, with the subsequent induction of potent, durable and specific anti-tumour T-cell responses in a melanoma model. These cryogels can be delivered in a minimally invasive manner, bypass the need for genetic modification of transplanted cancer cells and provide sustained release of immunomodulators. Altogether, these findings indicate the potential for cryogels to serve as a platform for cancer cell vaccinations.},
	keywords = {Animals, Cancer Vaccines, Cryogels, Dendritic Cells, Female, Melanoma, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Neoplasms, Experimental, T-Lymphocytes},
	issn = {2041-1723},
	doi = {10.1038/ncomms8556},
	author = {Bencherif, Sidi A and Warren Sands, R and Ali, Omar A and Li, Weiwei A and Lewin, Sarah A and Braschler, Thomas M and Shih, Ting-Yu and Verbeke, Catia S and Bhatta, Deen and Dranoff, Glenn and Mooney, David J}
}
