@article {601616,
	title = {A light-reflecting balloon catheter for atraumatic tissue defect repair},
	journal = {Sci Transl Med},
	volume = {7},
	number = {306},
	year = {2015},
	month = {2015 Sep 23},
	pages = {306ra149},
	abstract = {A congenital or iatrogenic tissue defect often requires closure by open surgery or metallic components that can erode tissue. Biodegradable, hydrophobic light-activated adhesives represent an attractive alternative to sutures, but lack a specifically designed minimally invasive delivery tool, which limits their clinical translation. We developed a multifunctional, catheter-based technology with no implantable rigid components that functions by unfolding an adhesive-loaded elastic patch and deploying a double-balloon design to stabilize and apply pressure to the patch against the tissue defect site. The device uses a fiber-optic system and reflective metallic coating to uniformly disperse ultraviolet light for adhesive activation. Using this device, we demonstrate closure on the distal side of a defect in porcine abdominal wall, stomach, and heart tissue ex vivo. The catheter was further evaluated as a potential tool for tissue closure in vivo in rat heart and abdomen and as a perventricular tool for closure of a challenging cardiac septal defect in a large animal (porcine) model. Patches attached to the heart and abdominal wall with the device showed similar inflammatory response as sutures, with 100\% small animal survival, indicating safety. In the large animal model, a ventricular septal defect in a beating heart was reduced to ,
	keywords = {Animals, Catheters, Rats, Wound Healing},
	issn = {1946-6242},
	doi = {10.1126/scitranslmed.aaa2406},
	author = {Ellen T Roche and Fabozzo, Assunta and Lee, Yuhan and Panagiotis Polygerinos and Friehs, Ingeborg and Schuster, Lucia and Whyte, William and Casar Berazaluce, Alejandra Maria and Bueno, Alejandra and Lang, Nora and Pereira, Maria J. N. and Feins, Eric and Wasserman, Steven and O{\textquoteright}Cearbhaill, Eoin D and Nikolay V. Vasilyev and Mooney, David J and Karp, Jeffrey M and Pedro J. del Nido and Conor J Walsh}
}
