@article {216741,
	title = {Guided bone regeneration using injectable vascular endothelial growth factor delivery gel},
	journal = {J Periodontol},
	volume = {84},
	number = {2},
	year = {2013},
	month = {2013 Feb},
	pages = {230-8},
	abstract = {BACKGROUND: Vascularization underlies the success of guided bone regeneration (GBR) procedures. This study evaluates the regenerative potential of GBR in combination with vascular endothelial growth factor (VEGF) delivery via an injectable hydrogel system.

METHODS: Critical-sized defects were created in rat calvariae, and GBR procedures were performed with a collagen membrane alone (control), or plus bolus delivery of VEGF, or plus application of VEGF-releasing hydrogels (VEGF-Alg). Four and 8 weeks after treatment, defect sites were evaluated with microcomputed tomographic and histomorphometric analyses for blood vessel and bone formation.

RESULTS: At 4 weeks, relative to the control condition, the bolus addition of VEGF did not affect blood vessel density within the defect site, yet the application of VEGF-Alg significantly (P ,
	keywords = {Alginates, Animals, Blood Vessels, Bone Diseases, Bone Regeneration, Collagen, Delayed-Action Preparations, Drug Delivery Systems, Guided Tissue Regeneration, Hydrogels, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Injections, Membranes, Artificial, Neovascularization, Physiologic, Osteogenesis, Rats, Rats, Inbred F344, Recombinant Proteins, Skull, Time Factors, Vascular Endothelial Growth Factor A, X-Ray Microtomography},
	issn = {1943-3670},
	doi = {10.1902/jop.2012.110684},
	author = {Kaigler, Darnell and Silva, Eduardo A and Mooney, David J}
}
