@article {1576544,
	title = {Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors},
	journal = {Nat Commun},
	volume = {11},
	number = {1},
	year = {2020},
	month = {2020 11 10},
	pages = {5696},
	abstract = {Poorly immunogenic tumors, including triple negative breast cancers (TNBCs), remain resistant to current immunotherapies, due in part to the difficulty of reprogramming the highly immunosuppressive tumor microenvironment (TME). Here we show that peritumorally injected, macroporous alginate gels loaded with granulocyte-macrophage colony-stimulating factor (GM-CSF) for concentrating dendritic cells (DCs), CpG oligonucleotides, and a doxorubicin-iRGD conjugate enhance the immunogenic death of tumor cells, increase systemic tumor-specific CD8 + T cells, repolarize tumor-associated macrophages towards an inflammatory M1-like phenotype, and significantly improve antitumor efficacy against poorly immunogenic TNBCs. This system also prevents tumor recurrence after surgical resection and results in 100\% metastasis-free survival upon re-challenge. This chemo-immunotherapy that concentrates DCs to present endogenous tumor antigens generated in situ may broadly serve as a facile platform to modulate the suppressive TME, and enable in situ personalized cancer vaccination.},
	keywords = {Animals, Antigens, Neoplasm, Biocompatible Materials, Biotechnology, Cancer Vaccines, CD8-Positive T-Lymphocytes, Dendritic Cells, Drug Delivery Systems, Female, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Immunologic Factors, Immunotherapy, Macrophages, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Neoplasm Recurrence, Local, Neoplasms, Triple Negative Breast Neoplasms, Tumor Microenvironment},
	issn = {2041-1723},
	doi = {10.1038/s41467-020-19540-z},
	author = {Wang, Hua and Najibi, Alexander J and Sobral, Miguel C and Seo, Bo Ri and Lee, Jun Yong and Wu, David and Li, Aileen Weiwei and Verbeke, Catia S and Mooney, David J}
}
