@article {1503075,
	title = {Compression-induced dedifferentiation of adipocytes promotes tumor progression},
	journal = {Sci Adv},
	volume = {6},
	number = {4},
	year = {2020},
	month = {2020 01},
	pages = {eaax5611},
	abstract = {Dysregulated physical stresses are generated during tumorigenesis that affect the surrounding compliant tissues including adipocytes. However, the effect of physical stressors on the behavior of adipocytes and their cross-talk with tumor cells remain elusive. Here, we demonstrate that compression of cells, resulting from various types of physical stresses, can induce dedifferentiation of adipocytes via mechanically activating Wnt/β-catenin signaling. The compression-induced dedifferentiated adipocytes (CiDAs) have a distinct transcriptome profile, long-term self-renewal, and serial clonogenicity, but do not form teratomas. We then show that CiDAs notably enhance human mammary adenocarcinoma proliferation both in vitro and in a xenograft model, owing to myofibrogenesis of CiDAs in the tumor-conditioned environment. Collectively, our results highlight unique physical interplay in the tumor ecosystem; tumor-induced physical stresses stimulate de novo generation of CiDAs, which feedback to tumor growth.},
	keywords = {Adipocytes, Animals, Cell Dedifferentiation, Cell Line, Tumor, Cell Transformation, Neoplastic, Disease Models, Animal, Disease Progression, Disease Susceptibility, Gene Expression Profiling, Humans, Mice, Neoplasms, Adipose Tissue, Stress, Mechanical, Xenograft Model Antitumor Assays},
	issn = {2375-2548},
	doi = {10.1126/sciadv.aax5611},
	author = {Li, Yiwei and Mao, Angelo S and Seo, Bo Ri and Zhao, Xing and Gupta, Satish Kumar and Chen, Maorong and Han, Yulong and Shih, Ting-Yu and Mooney, David J and Guo, Ming}
}
