@article {1434681,
	title = {Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir},
	journal = {Nat Biomed Eng},
	volume = {2},
	number = {6},
	year = {2018},
	month = {2018 Jun},
	pages = {416-428},
	abstract = {The clinical translation of regenerative therapy for the diseased heart, whether in the form of cells, macromolecules or small molecules, is hampered by several factors: the poor retention and short biological half-life of the therapeutic agent, the adverse side effects from systemic delivery, and difficulties with the administration of multiple doses. Here, we report the development and application of a therapeutic epicardial device that enables sustained and repeated administration of small molecules, macromolecules and cells directly to the epicardium via a polymer-based reservoir connected to a subcutaneous port. In a myocardial infarct rodent model, we show that repeated administration of cells over a four-week period using the epicardial reservoir provided functional benefits in ejection fraction, fractional shortening and stroke work, compared to a single injection of cells and to no treatment. The pre-clinical use of the therapeutic epicardial reservoir as a research model may enable insights into regenerative cardiac therapy, and assist the development of experimental therapies towards clinical use.},
	issn = {2157-846X},
	doi = {10.1038/s41551-018-0247-5},
	author = {Whyte, William and Ellen T Roche and Varela, Claudia E and Keegan Mendez and Islam, Shahrin and Hugh O{\textquoteright}Neill and Weafer, Fiona and Shirazi, Reyhaneh Neghabat and Weaver, James C and Nikolay V. Vasilyev and McHugh, Peter E and Murphy, Bruce and Duffy, Garry P and Conor J Walsh and Mooney, David J}
}
