@article {1303715,
	title = {A facile approach to enhance antigen response for personalized cancer vaccination},
	journal = {Nat Mater},
	year = {2018},
	month = {2018 Mar 05},
	abstract = {Existing strategies to enhance peptide immunogenicity for cancer vaccination generally require direct peptide alteration, which, beyond practical issues, may impact peptide presentation and result in vaccine variability. Here, we report a simple adsorption approach using polyethyleneimine (PEI) in a mesoporous silica microrod (MSR) vaccine to enhance antigen immunogenicity. The MSR-PEI vaccine significantly enhanced host dendritic cell activation and T-cell response over the existing MSR vaccine and bolus vaccine formulations. Impressively, a single injection of the MSR-PEI vaccine using an E7 peptide completely eradicated large, established TC-1 tumours in about 80\% of mice and generated immunological memory. When immunized with a pool of B16F10 or CT26 neoantigens, the MSR-PEI vaccine eradicated established lung metastases, controlled tumour growth and synergized with anti-CTLA4 therapy. Our findings from three independent tumour models suggest that the MSR-PEI vaccine approach may serve as a facile and powerful multi-antigen platform to enable robust personalized cancer vaccination.},
	issn = {1476-1122},
	doi = {10.1038/s41563-018-0028-2},
	author = {Li, Aileen Weiwei and Sobral, Miguel C and Badrinath, Soumya and Choi, Youngjin and Graveline, Amanda and Stafford, Alexander G and Weaver, James C and Dellacherie, Maxence O and Shih, Ting-Yu and Ali, Omar A and Kim, Jaeyun and Wucherpfennig, Kai W and Mooney, David J}
}
