@article {1092271, title = {Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation}, journal = {ACS Nano}, volume = {11}, number = {6}, year = {2017}, month = {2017 Jun 27}, pages = {5195-5214}, abstract = {We discuss the state of the art and innovative micro- and nanoscale technologies that are finding niches and opening up new opportunities in medicine, particularly in diagnostic and therapeutic applications. We take the design of point-of-care applications and the capture of circulating tumor cells as illustrative examples of the integration of micro- and nanotechnologies into solutions of diagnostic challenges. We describe several novel nanotechnologies that enable imaging cellular structures and molecular events. In therapeutics, we describe the utilization of micro- and nanotechnologies in applications including drug delivery, tissue engineering, and pharmaceutical development/testing. In addition, we discuss relevant challenges that micro- and nanotechnologies face in achieving cost-effective and widespread clinical implementation as well as forecasted applications of micro- and nanotechnologies in medicine.}, issn = {1936-086X}, doi = {10.1021/acsnano.7b01493}, author = {Alvarez, Mario M and Aizenberg, Joanna and Analoui, Mostafa and Andrews, Anne M and Bisker, Gili and Edward S Boyden and Kamm, Roger D and Karp, Jeffrey M and Mooney, David J and Oklu, Rahmi and Peer, Dan and Stolzoff, Michelle and Strano, Michael S and Trujillo-de Santiago, Grissel and Webster, Thomas J and Weiss, Paul S and Khademhosseini, Ali} }