#  Yevgeny Brudno 

Technology Development Fellow

 

 

 



   ![view.php_.jpg](/sites/g/files/omnuum6436/files/styles/hwp_4_5__480x600/public/mooneylab/files/view.php__2.jpg?itok=oekFgPLb) 

 



 

 location\_on Current: Assistant Professor at UNC/NC Sate joint BME Department 

 email [brudno1 \[at\] gmail.com](<mailto:brudno1 [at] gmail.com>) 

 



 

 **Education**

- PhD: Department of Chemistry and Chemical Biology. Harvard University. Advisor: David R. Liu
- BS: Chemistry, Biophysics. University of Pennsylvania *Magna Cum Laude*

 **Research Focus**

 Drug Delivery, Angiogenesis, Cancer Therapeutics

 **Publications**

 “In Vivo Disease Targeting through Click Chemistry.” **Brudno Y**, Kwee B, Desai R, Aizenberg M, Mooney DJ. *ChemMedChem. In press.*

 “Panel of 3D in vitro models to study impaired wound healing functions of diabetic foot ulcer-derived fibroblasts.” Maione AG, **Brudno Y**, Stojadinovic O, Park, LK, Smith, A, Tellechea A, Leal EC, Kearney C, Veves A, Tomic-Canic M, Mooney DJ, Garlick JA. *Tissue Engineering Part B. In Press.*

 “Refilling Drug Delivery Depots Through the Blood.” **Brudno Y\***, Silva EA\*, Kearney CJ, Lewin S, Aizenberg M, Mooney DJ. *Proceedings of the National Academy of Science* 111(35): 12722-7 (2014)

 “Fibroblasts Derived from Human Pluripotent Stem Cells Activate Angiogenic Responses In Vitro and In Vivo.” Shamis Y, Silva EA, Hewitt KJ, **Brudno Y**, Levenberg S, Mooney DJ, Garlick JA. *PLoS ONE 8(12): e83755. 2013*

 “Spatiotemporal Control Over Growth Factor Signaling for Therapeutic Angiogenesis.” **Brudno Y**, Ennet AB, Chen R, Aizenberg M, Mooney DJ. *Biomaterials.* 34(36):9201-9. 2013

 “Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.” Pastor WA, Pape UJ, Huang Y, Henderson HR, Lister R, Ko M, McLoughlin EM, **Brudno Y**, Mahapatra S, Kapranov P, Tahiliani M, Daley GQ, Liu S, Ecker JR, Milos PM, Agarwal S, Rao A. *Nature* 473:394. 2011

 “An In Vitro Translation, Selection, and Amplification System for Peptide Nucleic Acids". **Brudno Y**, Birnbaum ME, Kleiner RE, Liu DR. *Nature Chemical Biology* 6: 148-155. 2009

 “Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.” Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, **Brudno Y**, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A. *Science* 324(5929): 930-5. 2009

 “Recent progress toward the templated synthesis and directed evolution of sequence-defined synthetic polymers.” **Brudno Y**, Liu DR. *Chemistry &amp; Biology* 16(3): 265-76. 2009

 *"*DNA-Templated Polymerization of Side-Chain-Functionalized Peptide Nucleic Acid Aldehydes" Kleiner RE, **Brudno Y**, Birnbaum ME, Liu DR. *Journal of the American Chemical Society* 130 (14): 4646 – 4659. 2008

 **Patents**

 “Polymer evolution via templated synthesis.” Liu DR, Rosenbaum DR, **Brudno Y**. U.S. patent application no. 11916710.



 

 

 





 

 

- ## People
    
     [Alumni](/alumni)