#  Clickable, acid labile immunosuppressive prodrugs for in vivo targeting published in Biomaterial Science 

 





January 01, 2020

 

 

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 Congrats to [Hua ](/people/hua-wang)and team on their recent publication which describes DBCO-modified prodrugs of various immunosuppressive drugs and their targeted conjugation to azido-modified hydrogels *via* Click chemistry. Placement of these hydrogels in tissues facilitates sustained, local release of drugs and enables repeatable refilling via systemic administration of acid-labile prodrugs after drug exhaustion. Such an approach provides new possibilities for targeted immunosuppression in the context of allotransplantation.

 Check it out here: [Clickable, acid labile immunosuppressive prodrugs for in vivo targeting](https://pubs.rsc.org/en/content/articlelanding/2020/BM/C9BM01487J)



 

 

 



 

 

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