Our laboratory aims to make cellular and molecular therapies more effective and practical approaches to treat disease. Basic science studies are used to study the mechanisms by which chemical or mechanical signals are sensed by cells and alter cell function. The results of these studies are then used to design new biomaterials that provide desirable cues in a spatiotemporally-regulated manner to modulate the gene expression of interacting cells. These biomaterials are used in a variety of drug delivery, immunotherapy, and regenerative medicine projects to promote the regeneration or targeted destruction of tissues and organs in the body.